Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats

Fernandez-Garcia, Jose Manuel, Carrillo, Beatriz, Tezanos, Patricia, Pinos, Helena y Collado, Paloma . (2023) Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats. Molecular and Cellular Endocrinology 570 (2023) 111933

Ficheros (Some files may be inaccessible until you login with your e-spacio credentials)
Nombre Descripción Tipo MIME Size
Collado_Guirao_Paloma_Genistein_early.pdf Collado Guirao_Paloma_Genistein early.pdf application/pdf 8.31MB

Título Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats
Autor(es) Fernandez-Garcia, Jose Manuel
Carrillo, Beatriz
Tezanos, Patricia
Pinos, Helena
Collado, Paloma
Materia(s) Psicología
Abstract In the present work we analyzed the effects of postnatal exposure to two doses of genistein (10 μg/g or 50 μg/g) from postnatal (P) day 6 to P13, on the morphology of the arcuate nucleus (Arc). The analyses of Arc coronal brain sections at 90 days showed that the ArcMP had higher values in volume, Nissl-stained neurons and GPER-ir neurons in males than in females and the treatment with genistein abolished these sex differences in most of the parameters studied. Moreover, in males, but not in females, the GPER-ir neurons decreased in the ArcMP but increased in the ArcL with both doses of genistein. In the ArcLP, GPER-ir population increased with the lowest doses and decreased with the highest one in males. Our results confirm that the Arc subdivisions have differential vulnerability to the effects of genistein during development, depending on which neuromorphological parameters, dose and sex are analyzed.
Editor(es) Elsevier
Fecha 2023
Formato application/pdf
Identificador bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0003
http://e-spacio.uned.es/fez/view/bibliuned:DptoPSIBIO-FPSI-Articulos-Pcollado-0003
DOI - identifier https://doi.org/10.1016/j.mce.2023.111933
ISSN - identifier 0303-7207
Nombre de la revista Molecular and Cellular Endocrinology
Número de Volumen 570
Publicado en la Revista Molecular and Cellular Endocrinology 570 (2023) 111933
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Molecular and Cellular Endocrinology, is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.mce.2023.111933
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Molecular and Cellular Endocrinology, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.mce.2023.111933

Tipo de documento: Artículo de revista
Collections: Departamento de Psicobiología (UNED). Artículos
Set de artículo
Set de openaire
 
Versiones
Versión Tipo de filtro
Contador de citas: Google Scholar Search Google Scholar
Estadísticas de acceso: 39 Visitas, 8 Descargas  -  Estadísticas en detalle
Creado: Fri, 26 Jan 2024, 22:19:41 CET