Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects.

Fuentes-Verdugo, Esmeralda, López-Tolsa, Gabriela E., Pellón Suárez de Puga, Ricardo y Miguéns, Miguel . (2022) Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects.. Psychopharmacology, 239, 1359-1372.

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Título Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects.
Autor(es) Fuentes-Verdugo, Esmeralda
López-Tolsa, Gabriela E.
Pellón Suárez de Puga, Ricardo
Miguéns, Miguel
Materia(s) Psicología
Abstract Rationale Schedule-induced drinking (SID) is a behavioural phenomenon characterized by an excessive and repetitive drinking pattern with a distinctive temporal distribution that has been proposed as a robust and replicable animal model of compulsivity. Despite cannabis currently being the most widely consumed illicit drug, with growing interest in its clinical applications, little is known about the effects of ∆-9-tetrahydrocannabinol (THC) on SID. Objectives The effects of chronic and acute THC administration on SID acquisition, maintenance and extinction were studied, as were the effects of such administrations on the distinctive temporal distribution pattern of SID. Methods THC (5 mg/kg i.p.), or the corresponding vehicle, was administered to adult Wistar rats for 14 days in a row. Subsequently, THC effects on SID acquisition were tested during 21 sessions using a 1-h fixed-time 60-s food delivery schedule. Acute effects of THC were also evaluated after SID development. Finally, two extinction sessions were conducted to assess behavioural persistence. Results The results showed that previous chronic THC treatment delayed SID acquisition and altered the distinctive behavioural temporal distribution pattern during sessions. Moreover, acute THC administration after SID development decreased SID performance in animals chronically pre-treated with the drug. No great persistence effects were observed during extinction in animals pre-treated with THC. Conclusions These results suggest that chronic THC affects SID development, confirming that it can disrupt learning, possibly causing alterations in time estimation, and also leads to animals being sensitized when they are re-exposed to the drug after long periods without drug exposure.
Palabras clave THC
Cannabis
Adjunctive behaviour
Sensitization
Time estimation
Editor(es) Springer
Fecha 2022-05
Formato application/pdf
Identificador bibliuned:DptoPBI-FPSI-Articulos-Rpellon-0003
http://e-spacio.uned.es/fez/view/bibliuned:DptoPBI-FPSI-Articulos-Rpellon-0003
DOI - identifier https://doi.org/10.1007/s00213-021-05952-2
ISSN - identifier 0033-3158 - eISSN 1432-2072
Nombre de la revista Psychopharmacology
Número de Volumen 239
Página inicial 1359
Página final 1372
Publicado en la Revista Psychopharmacology, 239, 1359-1372.
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Psychopharmacology, is available online at the publisher's website: https://doi.org/10.1007/s00213-021-05952-2
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Psychopharmacology, está disponible en línea en el sitio web del editor: https://doi.org/10.1007/s00213-021-05952-2

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Creado: Thu, 08 Feb 2024, 07:54:01 CET