Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats

Íbias, Javier y Nazarian, Arbi . (2020) Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats. Journal of Psychopharmacology

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Título Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
Autor(es) Íbias, Javier
Nazarian, Arbi
Materia(s) Psicología
Abstract Abstract References Supplementary Material Get access Cite article Share options Information, rights and permissions Metrics and citations Abstract Background: Enhancement in cognitive impulsivity and the resulting alterations in decision making serve as a contributing factor for the development and maintenance of substance-use disorders. Nicotine-induced increases in impulsivity has been previously reported in male humans and rodents. Although the potential for sex differences in nicotine-induced impulsivity has not been examined. Aims and methods: In the present study, male and female Sprague Dawley rats were submitted to a delay discounting task, in which several consecutive measures of self-control were taken. Firstly, rats were tested with vehicle, and next with nicotine doses of 0.4 and 0.8 mg/kg. Thereafter, chronic treatment with bupropion started, and the animals were tested again. Half the animals continued to receive 0.8 mg/kg of nicotine, while the rest received nicotine and also a daily dose of 30 mg/kg of bupropion. Results: When the animals were first tested with nicotine, female rats showed a significant nicotine dose dependent increase of impulsive behaviour, whereas male rats only showed a decrease on their elections of the larger but delayed reward under the highest dose of 0.8 mg/kg of nicotine. Treatment with bupropion blocked the effect of nicotine on decision making in female rats, as they showed results close to their baseline levels. On the other hand, bupropion did not affect the nicotine-induced delay discounting in male rats. Conclusion: These findings demonstrate sexually dimorphic effects of nicotine on cognitive impulsivity which may help to shed light on nicotine use vulnerabilities observed in women.
Palabras clave Nicotine
delay discounting
impulsivity
sex differences
bupropion
Editor(es) SAGE
Fecha 2020-12
Formato application/pdf
Identificador bibliuned:DptoMCC-FPSI-Articulos-Jibias-0003
http://e-spacio.uned.es/fez/view/bibliuned:DptoMCC-FPSI-Articulos-Jibias-0003
DOI - identifier 10.1177/0269881120937543
ISSN - identifier 1461-7285
Nombre de la revista Journal of Psychopharmacology
Número de Volumen 34
Número de Issue 12
Página inicial 1382
Página final 1392
Publicado en la Revista Journal of Psychopharmacology
Idioma eng
Versión de la publicación acceptedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales This is an Accepted Manuscript of an article published by SAGE in Journal of Psychopharmacology, available at: https://doi.org/10.1177/026988112093754
Notas adicionales Este es el manuscrito aceptado del artículo publicado por SAGE en Journal of Psychopharmacology, disponible en línea: https://doi.org/10.1177/026988112093754

 
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Creado: Wed, 07 Feb 2024, 02:01:12 CET